Biogenetics & the 2014 Ebola Outbreak

From PLOS:

“Ebola virus is a zoonotic filovirus that causes a hemorrhagic fever syndrome in humans, with a high case-fatality rate. An epidemic that started in December 2013 or early in 2014, and which has spread to four West African countries (Guinea,Liberia, Sierra Leone, and Nigeria), has infected over 2000 individuals as of August 28 2014. While Ebola virus has caused several prior outbreaks in Africa, this is the largest ever to occur. Over half of all Ebola infections that have ever been documented have occurred in the context of the current outbreak, which is ongoing.”

Early Epidemic Dynamics of the West African 2014 Ebola Outbreak: Estimates Derived with a Simple (Sep 2014)
http://currents.plos.org/outbreaks/article/obk-14-0036-early-epidemic-dynamics-of-the-west-african-2014-ebola-outbreak-estimates-derived-with-a-simple-two-parameter-model/

Follow the bouncing ball ….

This Alnylam announcement of a $23mil DoD research grant, discusses the development of a treatment against a possible airborne biological terrorist attack.

Grant Gives Alnylam $23M For Anti-Ebola Virus Work (sep 2006)
http://www.bioworld.com/content/grant-gives-alnylam-23m-anti-ebola-virus-work-0

http://en.m.wikipedia.org/wiki/RNA_interference
http://en.m.wikipedia.org/wiki/Alnylam_Pharmaceuticals

Alnylam Gets $38.6 Million Grant For RNAi Antivirals (Aug 2007)
http://www.bioworld.com/content/alnylam-gets-386-million-grant-rnai-antivirals

Tekmira Gets $11.2M Commitment from Alnylam (Jan 2009)
http://www.contractpharma.com/contents/view_breaking-news/2009-01-08/tekmira-gets-11-2m-commitment-from-alnylam-/

Tekmira Announces $11.2 Million 3-Year Manufacturing and Development Commitment From Partner Alnylam (Jan 2009)
http://www.fiercebiotech.com/press-releases/tekmira-announces-11-2-million-3-year-manufacturing-and-development-commitment-partne

Alnylam Gets $38.6 Million Grant For RNAi Antivirals (Nov 2009)
http://www.highbeam.com/doc/1G1-211087117.html

But in Nov 2010 Big Pharma turns away from RNAi research saying it holds no promise but Alnylam and Tekmira stay on defiant. Or was big pharma ordered to back off? Just months previous DoD had invested millions more in RNAi ebola treatment research, which by mid-2013 was being praised once more.

Tekmira Nails $140M Defense Contract to Make RNAi Drug for Ebola (July 2010)
http://www.xconomy.com/seattle/2010/07/15/tekmira-nails-140m-defense-contract-to-make-rnai-drug-for-ebola/

Drug giants turn their backs on RNA interference (Nov 2010)
http://www.nature.com/news/2010/101123/full/468487a.html

As established above, Alnylam and Tekmira work together on the RNAi treatment as research partners, but also compete for millions in DoD contract dollars, ultimately culminating in each accusing the other of stealing research and patents. Tekmira seem to have favour of the courts winning millions in payout from Alnylam. Of course, as the above demonstrates, these millions going back and forth are pretty much all DoD dollars to begin with.

Alnylam files Patent Lawsuit Against Tekmira (Jan 2012)
http://www.bizjournals.com/boston/news/2012/01/17/alnylam-sues-tekmira.html

Alnylam Wins Rulings in Patent Infringement Case against Tekmira (Sep 2012)
http://www.firstwordpharma.com/node/1020121#axzz3D0nrJEcz

Alnylam to Pay Tekmira $65M to Settle RNAi Delivery Dispute (Nov 2012)
http://www.xconomy.com/boston/2012/11/12/alnylam-to-pay-tekmira-65m-to-settle-rnai-delivery-dispute/

Also from 2012, this interesting side-note regarding Alnylam …

Monsanto pays biotech firm Alnylam $29 million for IP rights (Aug 2012)
http://www.bizjournals.com/stlouis/blog/BizNext/2012/08/monsanto-forms-partnership-with-alnylam.html

Tekmira are ready to be approved for human trials, I see.

RNAi Therapeutics Ebola Candidate Achieves Critical Milestone (May 2013)
http://rnaitherapeutics.blogspot.com.au/2013/05/rnai-therapeutics-ebola-candidate.html

Tekmira Doses First Subject in Human Clinical Trial of TKM-Ebola (Jan 2014)
http://investor.tekmirapharm.com/releasedetail.cfm?ReleaseID=819313

Ebola outbreak in West Africa lends urgency to recently-funded research (April 2014)
http://blogs.nature.com/spoonful/2014/04/ebola-outbreak-in-west-africa-lends-urgency-to-recently-funded-research.html

And this time a side-note for Tekmira, receiving a $1.5 million payment from Monsanto for reaching a “specified program developments” milestone. Note the article states, “The potential value of the transaction could reach up to $86.2 million, following the successful completion of all program milestones.”

Tekmira Receives $1.5 Million Milestone Payment (July 2014)
http://finance.yahoo.com/news/tekmira-receives-1-5-million-230000330.html

Ebola: Behind the Experimental Drugs – Aug 2014
http://www.theglobeandmail.com/life/health-and-fitness/health/ebola-behind-the-experimental-drugs/article20055504/?page=all

FDA Places Ebola Drug Clinical Trial on Hold (Aug 2014)
http://globalbiodefense.com/2014/08/01/fda-places-ebola-drug-clinical-trial-hold/

Ebola ‘a deliberate attack on Africa’? (Aug 2014)
http://m.news24.com/nigeria/MyNews24/Ebola-a-deliberate-attack-on-Africa-20140811

Ebola: Are the Americans Running Away? (sep 2014)
http://www.herald.co.zw/ebola-are-the-americans-running-away/

Other interested Biowar Scientists?

What are US biowar researchers doing in the Ebola zone?
http://jonrappoport.wordpress.com/2014/08/01/what-are-us-biowar-researchers-doing-in-the-ebola-zone/

=================
Further Resources
=================

Reuters 12-1-1 (Rense Archive)
AIDS And Ebola Found To Use Same Mechanism To Spread In Body
http://www.rense.com/general17/aidsandebola.htm

WashPost – Deadly Viruses Used for Cure / Ebola-HIV hybrid may eventually help cystic fibrosis patients (march 2001)
http://m.sfgate.com/health/article/Deadly-Viruses-Used-for-Cure-Ebola-HIV-hybrid-2947114.php

Researchers identify a new variant of Ebola virus in Guinea (April 2014)
http://www.sciencedaily.com/releases/2014/04/140422113349.htm

New Ebola Strain Causing West Africa Outbreak
http://m.voanews.com/a/new-ebola-strain-causing-west-africa-outbreak/1895149.html

Study: Growing Guinea outbreak caused by new Ebola strain
http://www.cidrap.umn.edu/news-perspective/2014/04/study-growing-guinea-outbreak-caused-new-ebola-strain

Congo outbreak of Ebola unrelated to escalating West African epidemic
http://news.sciencemag.org/africa/2014/09/congo-outbreak-ebola-unrelated-escalating-west-african-epidemic

US Department of Defense (USAMRIID) & Tulane University Released This Bioengineered Ebola/Lassa Hybrid in Sierra Leone (GLP thread)
http://www.godlikeproductions.com/forum1/message2609009/pg1

Does anyone here know the secret of ebola? (LOP thread)
http://lunaticoutpost.com/showthread.php?tid=462802

Ebola in Nigeria: How Patrick Sawyer Knowingly Imported Ebola Into Nigeria [Full Story] (August 2014)
http://www.informationng.com/2014/08/ebola-in-nigeria-how-patrick-sawyer-deliberately-imported-ebola-into-nigeria-full-story.html

NYTimes – Ebola Outbreak. What you need to know 28-8-14
http://www.nytimes.com/interactive/2014/07/31/world/africa/ebola-virus-outbreak-qa.html

CDC Director: Ebola Outbreak ‘Spiraling Out Of Control,’ ‘Window Of Opportunity Is Closing’ (Sep 2014)
http://www.businessinsider.com.au/cdc-director-tom-frieden-ebola-update-2014-9

Gates Foundation Commits $50 Million To Ebola Containment Efforts (Sep 2014)
http://www.forbes.com/sites/davidkroll/2014/09/10/gates-foundation-commits-50-million-to-ebola-containment-efforts/

‘A lot of other people’ exposed to Ebola – apart from the four cases made public – have been transported back to the U.S., says vice president of transport company contracted to the State Department (Sep 2014)
http://www.dailymail.co.uk/news/article-2751379/A-lot-people-exposed-Ebola-apart-four-cases-public-transported-U-S-says-vice-president-transport-company-contracted-State-Department.html

—–

CIA’s fake vaccination programme criticised by Médecins Sans Frontières
Cover used by US intelligence to spy on Bin Laden in Pakistan ‘threatened immunisation work around the world’
http://www.theguardian.com/world/2011/jul/14/cia-fake-vaccination-medecins-frontieres

Alleged Fake CIA Vaccination Campaign Undermines Medical Care
http://www.doctorswithoutborders.org/news-stories/press-release/alleged-fake-cia-vaccination-campaign-undermines-medical-care

File Under WTF: Did the CIA Fake a Vaccination Campaign?
http://www.wired.com/2011/07/wtf-fake-vaccination/

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